BiDil (Isosorbide Dinitrate and Hydralazine Hydrochloride)
نویسندگان
چکیده
منابع مشابه
Hydralazine and isosorbide dinitrate: comparative central and regional hemodynamic effects when administered alone or in combination.
Central and regional hemodynamic studies were performed before and after the oral administration of 75 mg of hydralazine and/or 20 mg of isosorbide dinitrate in 15 patients with low-output congestive heart failure. Hydralazine increased mean cardiac output 17-25%, mean renal blood flow 19%, and limb blood flow 17% (all p < 0.05). Mean hepatic blood flow did not change significantly with hydrala...
متن کاملCombination of isosorbide dinitrate and hydralazine in blacks with heart failure.
BACKGROUND We examined whether a fixed dose of both isosorbide dinitrate and hydralazine provides additional benefit in blacks with advanced heart failure, a subgroup previously noted to have a favorable response to this therapy. METHODS A total of 1050 black patients who had New York Heart Association class III or IV heart failure with dilated ventricles were randomly assigned to receive a f...
متن کاملVasodilator treatment with isosorbide dinitrate and hydralazine in chronic heart failure.
Several reports have suggested that because isosorbide dinitrate and hydralazine have different and additive haemodynamic effects at rest in patients with chronic heart failure, these agents should be administered in combination. Some studies, however, indicate thay they are effective individually as well. Since most patients with heart failure are symptomatic only with activity, we examined th...
متن کاملPostural hypotension and tachycardia during hydralazine--isosorbide dinitrate therapy for chronic heart failure.
Supine and upright hemodynamic measurements were performed in 10 patients with chronic congestive heart failure, before and during vasodilator therapy with hydralazine and isosorbide dinitrate. This combination of drugs produced significant improvement in supine hemodynamic measurements, with the pulmonary capillary wedge pressure decreasing from 26 +/- 5 to 18 +/- 5 mm Hg (mean +/- SD, p less ...
متن کاملIsosorbide dinitrate plus hydralazine was effective for advanced heart failure in black patients.
and commentary also appear in ACP Journal Club . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr A Taylor, University of Minnesota Medical School, Minneapolis, MN, USA. [email protected] Source of funding: NitroMed. Isosorbide dinitrate plus hydralazine (ID+H) v placebo for heart failure (HF) in black ...
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ژورنال
عنوان ژورنال: Congestive Heart Failure
سال: 2006
ISSN: 1527-5299,1751-7133
DOI: 10.1111/j.1527-5299.2006.04960.x